Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Dec;68(12):7132-6.
doi: 10.1128/IAI.68.12.7132-7136.2000.

Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study

K F Jones  1 , S S Whitehead, M W Cunningham, V A Fischetti
Affiliations

Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study

K F Jones et al. Infect Immun. 2000 Dec.

Abstract

Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF patients relative to those of non-ARF patients, even though there was roughly equivalent exposure to group A streptococci. This suggests that antibodies to these molecules may not play a central role in the induction of ARF.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Kinetic enzyme-linked immunosorbent assay data showing the reactivity of ARF and uncomplicated SF/P patient sera for various streptococcal M protein and heart antigens. Each data point represents the mean of six readings. P values were determined by Student's t test.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Anderson H C, Kunkel H G, McCarty M. Quantitative antistreptokinase studies in patients infected with group A hemolytic streptococci: a comparison with serum antistreptolysin and gamma globulin levels with special reference to the occurrence of rheumatic fever. J Clin Investig. 1948;27:425–434. - PMC - PubMed
    1. Beachey E H, Bronze M S, Dale J B, Kraus W, Poirier T P, Sargent S J. Protective and autoimmune epitopes of streptococcal M proteins. Vaccine. 1988;6:192–196. - PubMed
    1. Beachey E H, Stollerman G H. Mediation of cytotoxic effects of streptococcal M protein by non-type specific antibody in human sera. J Clin Investig. 1973;52:2563–2570. - PMC - PubMed
    1. Bessen D, Fischetti V A. Influence of intranasal immunization with synthetic peptides corresponding to conserved epitopes of M protein on mucosal colonization by group A streptococci. Infect Immun. 1988;56:2666–2672. - PMC - PubMed
    1. Bessen D E, Veasy L G, Hill H R, Augustine N H, Fischetti V A. Serologic evidence for a class I group A streptococcal infection among rheumatic fever patients. J Infect Dis. 1995;172:1608–1611. - PubMed

Publication types

LinkOut - more resources