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. 2000 Dec;68(12):7132-6.
doi: 10.1128/IAI.68.12.7132-7136.2000.

Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study

K F Jones  1 , S S Whitehead, M W Cunningham, V A Fischetti
Affiliations

Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study

K F Jones et al. Infect Immun. 2000 Dec.

Abstract

Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF patients relative to those of non-ARF patients, even though there was roughly equivalent exposure to group A streptococci. This suggests that antibodies to these molecules may not play a central role in the induction of ARF.

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Figures

FIG. 1
FIG. 1
Kinetic enzyme-linked immunosorbent assay data showing the reactivity of ARF and uncomplicated SF/P patient sera for various streptococcal M protein and heart antigens. Each data point represents the mean of six readings. P values were determined by Student's t test.
See this image and copyright information in PMC

References

    1. Anderson H C, Kunkel H G, McCarty M. Quantitative antistreptokinase studies in patients infected with group A hemolytic streptococci: a comparison with serum antistreptolysin and gamma globulin levels with special reference to the occurrence of rheumatic fever. J Clin Investig. 1948;27:425–434. - PMC - PubMed
    1. Beachey E H, Bronze M S, Dale J B, Kraus W, Poirier T P, Sargent S J. Protective and autoimmune epitopes of streptococcal M proteins. Vaccine. 1988;6:192–196. - PubMed
    1. Beachey E H, Stollerman G H. Mediation of cytotoxic effects of streptococcal M protein by non-type specific antibody in human sera. J Clin Investig. 1973;52:2563–2570. - PMC - PubMed
    1. Bessen D, Fischetti V A. Influence of intranasal immunization with synthetic peptides corresponding to conserved epitopes of M protein on mucosal colonization by group A streptococci. Infect Immun. 1988;56:2666–2672. - PMC - PubMed
    1. Bessen D E, Veasy L G, Hill H R, Augustine N H, Fischetti V A. Serologic evidence for a class I group A streptococcal infection among rheumatic fever patients. J Infect Dis. 1995;172:1608–1611. - PubMed

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