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Review
. 2000 Nov;25(11):544-8.
doi: 10.1016/s0968-0004(00)01681-9.

Ubiquitin in chains

C M Pickart  1
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Free article
Review

Ubiquitin in chains

C M Pickart. Trends Biochem Sci. 2000 Nov.
Free article

Abstract

The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism.

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