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Review
. 2000 Nov;25(11):555-60.
doi: 10.1016/s0968-0004(00)01688-1.

Mitochondrial genetics and disease

E A Schon  1
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Free article
Review

Mitochondrial genetics and disease

E A Schon. Trends Biochem Sci. 2000 Nov.
Free article

Abstract

Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.

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