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. 2000 Nov 21;133(10):790-4.
doi: 10.7326/0003-4819-133-10-200011210-00011.

Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa

S Grinspoon  1 , E Thomas, S Pitts, E Gross, D Mickley, K Miller, D Herzog, A Klibanski
Affiliations

Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa

S Grinspoon et al. Ann Intern Med. .

Abstract

Background: Anorexia nervosa is highly prevalent among young women.

Objective: To determine prevalence and predictive factors for regional bone loss.

Design: Prospective cohort analysis.

Setting: University hospital.

Patients: 130 women with anorexia nervosa.

Measurements: Dual-energy x-ray absorptiometry.

Results: The prevalence of osteopenia (-1.0 SD >/= T-score > -2.5 SD) and osteoporosis (T-score </= -2.5 SD) was 50% and 13% for the anterior-posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site.

Conclusions: Bone mineral density is reduced at several skeletal sites in most women with anorexia nervosa. Weight, but not estrogen use, is a significant predictor of BMD in this population at all skeletal sites.

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References

    1. Pope HG, Jr, Hudson JI, Yurgelun-Todd D. Prevalence of anorexia nervosa and bulimia in three student populations. Int J Eating Disord. 1984;3:45–51.
    1. Lucas AR, Beard CM, O’Fallon WM, Kurland LT. 50-year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study. Am J Psychiatry. 1991;148:917–922. - PubMed
    1. Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3864–3870. - PubMed
    1. Biller BM, Saxe V, Herzog DB, Rosenthal DI, Holzman S, Klibanski A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab. 1989;68:548–554. - PubMed
    1. Rigotti NA, Nussbaum SR, Herzog DB, Neer RM. Osteoporosis in women with anorexia nervosa. N Engl J Med. 1984;311:1601–1606. - PubMed

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