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Review
. 2000 Nov 27;151(5):F37-42.
doi: 10.1083/jcb.151.5.f37.

The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility

M E Porter  1 , W S Sale
Affiliations
Review

The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility

M E Porter et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
(A) Schematic diagram of the flagellar axoneme in cross-section. The Chlamydomonas mutations that affect the assembly or function of specific structures are also indicated. The inner and outer dynein arms are multisubunit ATPases that generate relative sliding movements between the outer doublet microtubules. The interdoublet sliding is normally constrained by interdoublet linkages and attachment to the basal body, leading to flagellar bending. The radial spokes and central pair microtubules with their associated projections coordinate the dynein-induced sliding to generate a variety of waveforms. (B) The arrangement of the inner dynein arms and other structures on the A-tubule of the outer doublet, as viewed from the B-tubule of the adjacent doublet. The structures repeat along the length of the outer doublet microtubule with a 96-nm periodicity, referred to as the 96-nm repeat. The proximal end (adjacent to the cell body) is to the left. The outer arms (OA) are on the top and the radial spokes (RS) are on the bottom. The I1 dynein is the trilobed structure proximal to the first radial spoke in each repeat. The three p28-associated dyneins are correlated with the three gray lobes. The crescent-shaped structure above the second radial spoke (S2) is associated with the DRC. One of the centrin-associated dyneins is located in the adjacent striped lobe. The postulated locations of CK1 and PP2A are also indicated.
Figure 2
Figure 2
(A) Schematic diagram of the proposed location of axonemal kinases and phosphatases. The proposed locations of several axonemal kinases and phosphatases are also shown in relationship to the outer arms (ODA), the inner arms (IDA), the radial spokes, and the central pair microtubules. These positions are approximate, as they are based on indirect methods. Determining the precise locations will require direct, high resolution structural techniques. (B) General model for motor-regulatory enzyme docking structures. The protein complexes that bind motors to specific cargoes may also be adapted to bind regulatory kinases and phosphatases to the same site (see text).
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