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Review
. 2000 Nov;106(10):1203-4.
doi: 10.1172/JCI11468.

The mechanisms of estrogen regulation of bone resorption

B L Riggs  1
Affiliations
Review

The mechanisms of estrogen regulation of bone resorption

B L Riggs. J Clin Invest. 2000 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Major cytokines in the bone microenvironment that regulate OC function. Stimulatory factors are shown in orange and inhibitory factors are shown in blue. Positive (+) or negative (–) effects of E on these regulatory factors are shown in red. The blow-up circle shows that TNF-α and RANKL act through separate receptors, but both activate the NF-κB and JNK intracellular signaling pathways. GM-CSF, granulocyte macrophage-colony-stimulating factor.
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Comment on

References

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    1. Hofbauer LC, et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000;15:2–12. - PubMed

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