Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jan;28(1):69-76.

Age trends in human chiasma frequencies and recombination fractions. II. Method for analyzing recombination fractions and applications to the ABO:nail-patella linkage

R C Elston, E Lange, K K Namboodiri

Age trends in human chiasma frequencies and recombination fractions. II. Method for analyzing recombination fractions and applications to the ABO:nail-patella linkage

R C Elston et al. Am J Hum Genet. 1976 Jan.

Abstract

A new method is presented for studying the relationship between human recombination fractions and parental age at the time of conception. Assuming the sex specific recombination fraction to be a linear function of age, a feasible computer algorithm is described whereby the likelihood of multigenerational families can be calculated. Using this method and the likelihood ratio test, it is found that for the ABO:nail-patella linkage age (P= .17)is more significant than sex (p= .23) in its effect on the recombination fraction. The age effect, if it is real, appears to be limited to males: the paternal recombination fraction decreases by .0062(+/- .0036) per year.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1963 Jun;15(2):182-3 - PubMed
    1. Ann Hum Genet. 1966 Nov;30(2):193-5 - PubMed
    1. Ann Hum Genet. 1956 May;20(4):348-60 - PubMed
    1. Heredity (Edinb). 1963 Feb;18:107-8 - PubMed
    1. Ann Hum Genet. 1961 May;25:25-7 - PubMed

Publication types

Substances

LinkOut - more resources