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. 2000 Nov;48(11):1786-9.
doi: 10.1248/cpb.48.1786.

Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation

S S Lim  1 , S H Jung, J Ji, K H Shin, S R Keum
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Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation

S S Lim et al. Chem Pharm Bull (Tokyo). 2000 Nov.

Abstract

Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.

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