Review
doi: 10.1080/15216540050176520.
Establishing a left-right axis in the embryo
Affiliations
- PMID: 11087114
- DOI: 10.1080/15216540050176520
Item in Clipboard
Review
Establishing a left-right axis in the embryo
IUBMB Life.
2000 Jul.
Free article
Abstract
Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.
Similar articles
-
Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration.Nat Rev Genet. 2006 Apr;7(4):283-93. doi: 10.1038/nrg1830. Nat Rev Genet. 2006. PMID: 16543932 Review.
-
A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes.J Exp Zool B Mol Dev Evol. 2008 Jan 15;310(1):41-53. doi: 10.1002/jez.b.21121. J Exp Zool B Mol Dev Evol. 2008. PMID: 16838294 Review.
-
Vertebrate left-right asymmetry: old studies and new insights.Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):505-16. Cell Mol Biol (Noisy-le-grand). 1999. PMID: 10512183 Review.
-
The evolution of left-right asymmetry in chordates.Bioessays. 2002 Nov;24(11):1004-11. doi: 10.1002/bies.10171. Bioessays. 2002. PMID: 12386931 Review.
-
[Molecular mechanism for left-right axis formation].Tanpakushitsu Kakusan Koso. 2005 May;50(6 Suppl):738-43. Tanpakushitsu Kakusan Koso. 2005. PMID: 15926508 Review. Japanese. No abstract available.
Cited by
-
Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.Mol Biol Cell. 2002 Sep;13(9):3096-106. doi: 10.1091/mbc.e02-04-0195. Mol Biol Cell. 2002. PMID: 12221118 Free PMC article.
-
A Rare Case of Recurrent Pneumonia in Heterotaxy Syndrome, Polysplenia/Left Isomerism.Cureus. 2021 Oct 26;13(10):e19055. doi: 10.7759/cureus.19055. eCollection 2021 Oct. Cureus. 2021. PMID: 34858743 Free PMC article.
-
Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huët anomaly.Am J Hum Genet. 2022 Oct 6;109(10):1909-1922. doi: 10.1016/j.ajhg.2022.08.008. Epub 2022 Aug 30. Am J Hum Genet. 2022. PMID: 36044892 Free PMC article.
-
Knockdown of Mns1 Increases Susceptibility to Craniofacial Defects Following Gastrulation-Stage Alcohol Exposure in Mice.Alcohol Clin Exp Res. 2018 Nov;42(11):2136-2143. doi: 10.1111/acer.13876. Epub 2018 Sep 10. Alcohol Clin Exp Res. 2018. PMID: 30129265 Free PMC article.
-
Gene-alcohol interactions in birth defects.Curr Top Dev Biol. 2023;152:77-113. doi: 10.1016/bs.ctdb.2022.10.003. Epub 2022 Nov 14. Curr Top Dev Biol. 2023. PMID: 36707215 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
