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. 2000 Nov 14;55(9):1410-2.
doi: 10.1212/wnl.55.9.1410.

Decreased striatal dopaminergic innervation in REM sleep behavior disorder

R L Albin  1 , R A Koeppe, R D Chervin, F B Consens, K Wernette, K A Frey, M S Aldrich
Affiliations

Decreased striatal dopaminergic innervation in REM sleep behavior disorder

R L Albin et al. Neurology. .

Abstract

REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.

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