Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2000 Dec 5;97(25):13473-5.
doi: 10.1073/pnas.250380097.

Epidermal stem cells: properties, markers, and location

R M Lavker  1 , T T Sun
Affiliations
Comment

Epidermal stem cells: properties, markers, and location

R M Lavker et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A schematic diagram of an epidermo-pilosebaceous unit in hair-bearing skin. The unit consists of the epidermis and the hair follicle with its associated sebaceous gland. The bulge contains a population of putative keratinocyte stem cells that can give rise to (pathway 1) a population of pluripotent and rapidly dividing progenitor (transit amplifying) cells in the matrix that yields the hair shaft. Alternatively, the bulge stem cells can give rise to the stem/progenitor cells of the epidermis (pathway 2). It is hypothesized here that the epidermal stem cell represents a form of bulge-derived, young transit amplifying cell (SC/TA1,2… ?). The long, curved arrow denotes the demonstrated capability of adult epidermal cells to form a new hair follicle in response to appropriate mesenchymal stimuli (46, 47). B, bulge; E, epidermis; FP, follicular or dermal papilla; M, matrix keratinocytes; ORS, outer root sheath; S, hair shaft; SC, stem cells; SG, sebaceous gland; TA, transit amplifying cells.
See this image and copyright information in PMC

Comment on

References

    1. Fuchs E, Segre J A. Cell. 2000;100:143–155. - PubMed
    1. Weissman I L. Cell. 2000;100:157–168. - PubMed
    1. Potten C S, Hendry J H. Int J Radiat Biol Relat Stud Phys Chem Med. 1973;24:537–540. - PubMed
    1. Lavker R M, Sun T-T. Science. 1982;215:1239–1241. - PubMed
    1. Potten C S, Morris R J. J Cell Sci Suppl. 1988;10:45–62. - PubMed