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Comment
. 2000 Dec 5;97(25):13473-5.
doi: 10.1073/pnas.250380097.

Epidermal stem cells: properties, markers, and location

R M Lavker  1 , T T Sun
Affiliations
Comment

Epidermal stem cells: properties, markers, and location

R M Lavker et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
A schematic diagram of an epidermo-pilosebaceous unit in hair-bearing skin. The unit consists of the epidermis and the hair follicle with its associated sebaceous gland. The bulge contains a population of putative keratinocyte stem cells that can give rise to (pathway 1) a population of pluripotent and rapidly dividing progenitor (transit amplifying) cells in the matrix that yields the hair shaft. Alternatively, the bulge stem cells can give rise to the stem/progenitor cells of the epidermis (pathway 2). It is hypothesized here that the epidermal stem cell represents a form of bulge-derived, young transit amplifying cell (SC/TA1,2… ?). The long, curved arrow denotes the demonstrated capability of adult epidermal cells to form a new hair follicle in response to appropriate mesenchymal stimuli (46, 47). B, bulge; E, epidermis; FP, follicular or dermal papilla; M, matrix keratinocytes; ORS, outer root sheath; S, hair shaft; SC, stem cells; SG, sebaceous gland; TA, transit amplifying cells.
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