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Review
. 2000 Nov 21;97(24):12945-7.
doi: 10.1073/pnas.97.24.12945.

Ubiquitin in retrovirus assembly: actor or bystander?

V M Vogt  1
Affiliations
Review

Ubiquitin in retrovirus assembly: actor or bystander?

V M Vogt. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Structure of HIV-1 and RSV Gag proteins. Vertical lines denote sites of cleavage by the viral protease that liberates the mature proteins indicated. The vertical black bar represents the late domain, indicated by the core sequence PTAP or PPPY for these proteins.
Figure 2
Figure 2
Speculative representation of late stage in retroviral budding. The Gag molecules have formed a spherical particle ready to pinch off from the plasma membrane. Some ubiquitin molecules (red star), both free and conjugated to Gag, are present in the nascent virus. A ubiquitin ligase (blue rectangle) is recruited to the site of budding by the Gag late domain, and it conjugates ubiquitin to some of the Gag molecules and perhaps to cellular proteins (green oval). Other cellular proteins (yellow triangle) may bind to these ubiquitin conjugates, setting up the machinery to pinch off the virus bud. (Adapted from ref. .)
See this image and copyright information in PMC

Comment on

References

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