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. 2000 Nov 11;356(9242):1657-8.
doi: 10.1016/S0140-6736(00)03165-2.

Association between acute hypobaric hypoxia and activation of coagulation in human beings

B Bendz, M Rostrup, K Sevre, T O Andersen, P M Sandset

Association between acute hypobaric hypoxia and activation of coagulation in human beings

B Bendz et al. Lancet. .

Abstract

The risk of venous thrombosis is thought to be increased by flying. In a study of 20 healthy male volunteers who were suddenly exposed to a hypobaric environment similar to that encountered within aeroplane cabins, markers of activated coagulation transiently Increased by two-fold to eight-fold. We suggest that hypobaric hypoxia, with sedentariness and dehydration, may cause this increased risk of venous thrombosis.

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Comment in

  • Hypobaric hypoxia.
    Bärtsch P, Straub PW, Haeberli A. Bärtsch P, et al. Lancet. 2001 Mar 24;357(9260):955-6. doi: 10.1016/S0140-6736(00)04226-4. Lancet. 2001. PMID: 11289367 No abstract available.
  • Hypobaric hypoxia.
    Basnyat B. Basnyat B. Lancet. 2001 Mar 24;357(9260):956. doi: 10.1016/S0140-6736(00)04227-6. Lancet. 2001. PMID: 11289368 No abstract available.
  • Hypobaric hypoxia.
    Ozsoylu S. Ozsoylu S. Lancet. 2001 Mar 24;357(9260):956. doi: 10.1016/S0140-6736(05)71653-6. Lancet. 2001. PMID: 11289369 No abstract available.
  • Venous thromboembolic disease in pilots.
    Johnston R, Evans A. Johnston R, et al. Lancet. 2001 Nov 17;358(9294):1734. doi: 10.1016/S0140-6736(01)06761-7. Lancet. 2001. PMID: 11728589 No abstract available.

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