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Clinical Trial
. 2000 Dec;74(24):11636-41.
doi: 10.1128/jvi.74.24.11636-11641.2000.

The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses

A Antonsson  1 , O Forslund, H Ekberg, G Sterner, B G Hansson
Affiliations
Clinical Trial

The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses

A Antonsson et al. J Virol. 2000 Dec.

Abstract

Human papillomaviruses (HPV) are epitheliotropic viruses, with some types suggested to be associated with skin cancer. In this study, swab samples collected from five different sites on the skin of renal transplant recipients, dialysis patients, and age- and sex-matched healthy controls were analyzed for HPV DNA by a newly designed PCR test. Most individuals were found to have asymptomatic HPV infections; more specifically, 94% of the renal transplant patients, 82% of the dialysis patients, and 80% of the healthy controls were positive for HPV DNA. The multiplicity of the HPVs detected was astounding: 20 previously described and 30 putatively new types were identified by cloning and sequencing of 33 samples from 13 individuals. These results demonstrate that normal human skin harbors an array of papillomaviruses, most of them previously unknown.

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Figures

FIG. 1
FIG. 1
Phylogenetic analysis of the HPV type candidates FA1 to FA42, the established papillomaviruses (indicated in boldface) of the supergroups β, γ, ɛ, and δ, and four HPV types of supergroup α based on neighbor-joining evaluation of a segment of the L1 gene. Only 4 out of the total of about 70 papillomavirus types of the supergroup α were used in the analysis.
See this image and copyright information in PMC

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