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Review
. 2000 Oct;53(5):262-9.
doi: 10.1136/mp.53.5.262.

Hodgkin's disease and the Epstein-Barr virus

K J Flavell  1 , P G Murray
Affiliations
Review

Hodgkin's disease and the Epstein-Barr virus

K J Flavell et al. Mol Pathol. 2000 Oct.

Abstract

Hodgkin's disease is an unusual cancer because the malignant cells constitute only a minority of the total tumour mass and, as a consequence, the study of these cells has been a major challenge. Recently, the application of newer technologies, such as single cell polymerase chain reaction (PCR) and gene expression array analysis, to the study of Hodgkin's disease have yielded new insights into the pathogenesis of this tumour. In addition, the recognition that a proportion of Hodgkin's disease tumours harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of Hodgkin's disease in some cases. This review summarises current knowledge of the pathogenesis of Hodgkin's disease with particular emphasis on the association with EBV.

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Figures

Figure 1
Figure 1
Double labelling of malignant Hodgkin-Reed Sternberg (HRS) cells showing co-expression of Epstein-Barr virus early RNAs (EBERs; brown/black) and latent membrane protein 1 (LMP1; red).
Figure 2
Figure 2
Immunohistochemical detection of nuclear factor κB (NF-κB) in the nuclei of Hodgkin-Reed Sternberg (HRS) cells and other lymphoid cells from Hodgkin's disease using an antibody that recognises the nuclear localisation signal of the p65 subunit of NF-κB.
Figure 3
Figure 3
Immunohistochemical detection of latent membrane protein 2 (LMP2) in Hodgkin's disease.
See this image and copyright information in PMC

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