Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000:42 Suppl 1:26-7.
doi: 10.1159/000054848.

New insights into the mechanisms and sites of action of lamotrigine

J M Langosch  1 , X Y Zhou, H Grunze, J Walden
Affiliations

New insights into the mechanisms and sites of action of lamotrigine

J M Langosch et al. Neuropsychobiology. 2000.

Abstract

This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids. In the range of therapeutic plasma levels, synaptic transmission was not affected.

PubMed Disclaimer

Publication types