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Review
. 2000;2(2):101-14.
doi: 10.1186/ar75. Epub 2000 Feb 9.

Death, autoantigen modifications, and tolerance

P J Utz  1 , T J Gensler, P Anderson
Affiliations
Review

Death, autoantigen modifications, and tolerance

P J Utz et al. Arthritis Res. 2000.

Abstract

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.

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