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Review
. 2000;2(3):203-4.
doi: 10.1186/ar87. Epub 2000 Apr 27.

Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction

R Holmdahl  1
Affiliations
Review

Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction

R Holmdahl. Arthritis Res. 2000.
No abstract available

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Figures

Figure 1
Figure 1
Some of the mechanisms proposed for the role of DR in RA. (a) DR molecules provides peptides for binding to other MHC molecules which will trigger T cells that regulate pahogenic T cells. (b) DR- self peptide complexes select the T cell repertoire that may have a regulatory impact on the activation of pathogenic T cells. (c) DR molecules bind self peptides, which may or may not be derived from joint tissue, that trigger pathogenic T cells. (d) Another possibility is that DR molecules binds peptides derived from infectious agents that may persist in the joints or give rise to a self cross-reactive T cells. Subsequently the activated T cells could induce, modulate or regulate the erosive destruction of the joints.
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