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Review
. 2000;2(5):344-7.
doi: 10.1186/ar110. Epub 2000 Jun 8.

Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis

J C Edwards  1
Affiliations
Review

Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis

J C Edwards. Arthritis Res. 2000.

Abstract

Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.

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Figures

Figure 1
Figure 1
Schematic representation of a normal synovium. The intima contains specialised fibroblasts (black, indicated by arrows) expressing VCAM-1, DAF and UDPGD, and specialised macrophages (dark grey, indicated by arrow) expressing Fcγ RIIIa. The deeper subintima contains relatively unspecialised counterparts (labelled).
See this image and copyright information in PMC

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