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Comment
. 2000 Dec 5;97(25):13461-3.
doi: 10.1073/pnas.011511198.

Interplay of intrinsic and extrinsic signals in yeast differentiation

H D Madhani  1
Affiliations
Comment

Interplay of intrinsic and extrinsic signals in yeast differentiation

H D Madhani. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Developmental options of S. cerevisiae cell types. Haploid a or α cells differentiate into a filamentous form in response to glucose starvation (see article by Cullen and Sprague (2) in this issue). Haploid cells of the opposite mating type respond to peptide mating pheromones to fuse, forming a/α diploid cells. In contrast to the haploid cell types, a/α cells switch to filamentous growth in response to nitrogen starvation in the presence of abundant glucose. When simultaneously starved for nitrogen and glucose, a/α cells undergo meiosis and sporulation to produce haploid gametes.
Figure 2
Figure 2
Hypothesis for how cell type determines the response to signals. (A) Formal model. There exist two mechanisms for driving filamentous growth: a glucose starvation pathway and a nitrogen starvation pathway. a1-α2 represses the glucose starvation mechanism whereas a hypothetical factor X represses the nitrogen starvation mechanism. a1-α2 represses the expression of X, restricting its expression to a and α cells. (B) Molecular model. Genes required for filamentous growth are regulated by either a transcription factor that is activated by glucose starvation (G) or a transcription factor activated by nitrogen starvation (N). a1/α2 represses G whereas X represses N.
See this image and copyright information in PMC

Comment on

References

    1. Madhani H D, Fink G R. Trends Cell Biol. 1998;8:348–353. - PubMed
    1. Cullen P J, Sprague G F., Jr Proc Natl Acad Sci USA. 2000;97:13619–13624. - PMC - PubMed
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