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Review
. 2000 Nov;23(11):803-7.
doi: 10.1002/clc.4960231128.

Bosentan and the endothelin system in congestive heart failure

S H Ellahham  1 , V Charlon, Z Abassi, K A Calis, W K Choucair
Affiliations
Review

Bosentan and the endothelin system in congestive heart failure

S H Ellahham et al. Clin Cardiol. 2000 Nov.

Abstract

The endothelin system appears to play an important role in the pathophysiology of congestive heart failure (CHF). Endothelin receptor antagonists represent a novel class of agents that are being evaluated for their potential benefits in treating various cardiovascular disorders. Bosentan is an orally active endothelin receptor antagonist that has been studied for the treatment of CHF. Early clinical experience with bosentan has confirmed some benefits on hemodynamic parameters in patients with CHF. Its role in slowing the progression of the disease and improving survival remains to be elucidated.

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