Comparative Study
Activity of 6-methyl-8-substituted ergolines against the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma
- PMID: 1109784
Item in Clipboard
Comparative Study
Activity of 6-methyl-8-substituted ergolines against the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma
Cancer Res.
1975 Jan.
Abstract
The ability of a series of 8-beta-carboxamido ergolines, 8-formamido ergolines, and 8-methyl ergolines to cause regressions of established dimethylbenz[a]anthracene-induced mammary carcinomas was compared to some ergot alkaloids. Although most of the ergoline derivatives depressed serum prolactin concentrations in rats, only a few had pronounced effects against the dimethylbenz[a]anthracene-induced mammary carcinoma in rats. Some derivatives from each of the three groups of substituted ergolines gave comparable activities against the dimethylbenz[a]anthracene-induced mammary carcinoma.
Similar articles
-
Comparative effects of a series of prolactin inhibitors, 17beta-estradiol and 2alpha-methyldihydrotestosterone propionate, on growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas.Cancer Res. 1977 Nov;37(11):3932-8. Cancer Res. 1977. PMID: 409489 Review.
-
Predominant role of prolactin in stimulating the growth of 7, 12-dimethylbenz(a)anthracene-induced rat mammary tumor.Cancer Res. 1977 Apr;37(4):1216-9. Cancer Res. 1977. PMID: 191182
-
Effects of 4-nitroestrone 3-methyl ether on dimethylbenz(a)anthracene-induced mammary tumors.Cancer Res. 1983 Jun;43(6):2611-7. Cancer Res. 1983. PMID: 6406049
-
Effects of ergocornine and ergocryptine on growth of 7,12-dimethylbenzanthracene-induced mammary tumors in rats.Cancer Res. 1971 Jul;31(7):1051-3. Cancer Res. 1971. PMID: 5560385 No abstract available.
-
Influence of ergot alkaloids on pituitary prolactin and prolactin-dependent processes.J Pharm Sci. 1973 May;62(5):699-715. doi: 10.1002/jps.2600620502. J Pharm Sci. 1973. PMID: 4574586 Review. No abstract available.