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Review
. 2000 Dec;116(6):873-82.
doi: 10.1085/jgp.116.6.873.

Ryanodine receptor adaptation

M Fill  1 , A Zahradníková, C A Villalba-Galea, I Zahradník, A L Escobar, S Györke
Affiliations
Review

Ryanodine receptor adaptation

M Fill et al. J Gen Physiol. 2000 Dec.
No abstract available

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Figures

Figure 1
Figure 1
(A) The modal gating kinetic scheme (Villalba-Galea et al. 1998) shows the Ca2+-dependent transitions involved in RyR activation, modal gating (C4-O1-C5 and C5-O2-C4), and inactivation (O1-I, C1-C2, C2-C3, C3-C4, and C4-O1). The rate constants for the transitions between states are listed in Table . (B) Single-channel recordings simulated using the Monte Carlo method. The Ca2+ stimulus, sample single-channel sweeps, and an ensemble record generated from 100 sweeps are shown. These simulations show that each of two consecutive fast incremental Ca2+ elevations (<1 μM) generate transient bursts of channel activity. (C) Single RyR response to a single large Ca2+ elevation to 1 mM. The Ca2+ stimulus, sample single-channel sweeps, and an ensemble record are shown. (D) Single RyR response to a fast small Ca2+ elevation to 1 μM. Only the Ca2+ stimulus and an ensemble record are shown. (E) Single RyR response to a fast small Ca2+ elevation to 1 μM with a large (100 μM) Ca2+ spike at its leading edge. Only the Ca2+ stimulus and an ensemble record are shown. (F) Single RyR response to a 100-ms ramp-like Ca2+ elevation to 1 μM. Only the Ca2+ stimulus and an ensemble record are shown.
See this image and copyright information in PMC

References

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