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. 2000 Jul;48(3):249-50.
doi: 10.1023/a:1006404825356.

The effect of anticonvulsant drugs on blood levels of methotrexate

M Riva  1 , G Landonio, C A Defanti, S Siena
Affiliations

The effect of anticonvulsant drugs on blood levels of methotrexate

M Riva et al. J Neurooncol. 2000 Jul.

Abstract

The reduced bioavailability of chemotherapeutic agents is one of the reasons that explains the limited efficacy of adjuvant chemotherapy in high grade glioma patients. We report how even the results of high dose sequential chemotherapy can be influenced by antiepileptic drugs.

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