Review
doi: 10.1016/s0952-7915(00)00162-x.
The role of different subsets of T regulatory cells in controlling autoimmunity
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- PMID: 11102772
- DOI: 10.1016/s0952-7915(00)00162-x
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Review
The role of different subsets of T regulatory cells in controlling autoimmunity
Curr Opin Immunol.
2000 Dec.
Abstract
T regulatory cells-in addition to clonal deletion and anergy-are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
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