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Review
. 2000 Dec;12(6):704-11.
doi: 10.1016/s0952-7915(00)00166-7.

Antigen-specific therapy for autoimmune disease

L C Harrison  1 , D A Hafler
Affiliations
Review

Antigen-specific therapy for autoimmune disease

L C Harrison et al. Curr Opin Immunol. 2000 Dec.

Abstract

The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.

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