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Review
. 2000 Dec;11(6):532-9.
doi: 10.1016/s0958-1669(00)00141-5.

Hydroxynitrile lyases in stereoselective catalysis

F Effenberger  1 , S Förster, H Wajant
Affiliations
Review

Hydroxynitrile lyases in stereoselective catalysis

F Effenberger et al. Curr Opin Biotechnol. 2000 Dec.

Abstract

(R)- as well as (S)-cyanohydrins are now easily available as a result of the excellent accessibility, the relatively high stability and the easy handling of hydroxynitrile lyases (HNLs). The optimization of reaction conditions (solvent, temperature, and using site-directed mutagenesis, etc.) has enabled HNL-catalyzed preparations of optically active cyanohydrins on a technical scale. The enantioselectivity of chiral metal-complex-catalyzed additions of trimethylsilyl cyanide to aldehydes has been improved, but is, by far, not yet competitive with the HNL-catalyzed reactions.

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