Review
doi: 10.1038/80784.
From structure to function: approaches and limitations
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- PMID: 11104008
- DOI: 10.1038/80784
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Review
From structure to function: approaches and limitations
Nat Struct Biol.
2000 Nov.
Abstract
This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.
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