Whither genomics?

doi:10.1186/gb-2000-1-1-comment003

Review

. 2000;1(1):COMMENT003.

doi: 10.1186/gb-2000-1-1-comment003. Epub 2000 Jun 9.

Whither genomics?

A W Murray¹

Affiliations

PMID: 11104516
PMCID: PMC138820
DOI: 10.1186/gb-2000-1-1-comment003

Review

Whither genomics?

A W Murray. Genome Biol. 2000.

. 2000;1(1):COMMENT003.

doi: 10.1186/gb-2000-1-1-comment003. Epub 2000 Jun 9.

Author

A W Murray¹

Affiliation

¹ Department of Physiology, University of California San Francisco, CA 94143, USA. amurray@mcb.harvard.edu.

PMID: 11104516
PMCID: PMC138820
DOI: 10.1186/gb-2000-1-1-comment003

Abstract

The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individual biological pathways and to use the resulting information to yield knowledge about general principles that explain the functions and evolution of life.

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Comment in

Functional genomics does not have to be limited to a few select organisms.
Crawford DL. Crawford DL. Genome Biol. 2001;2(1):INTERACTIONS1001. doi: 10.1186/gb-2001-2-1-interactions1001. Epub 2001 Jan 12. Genome Biol. 2001. PMID: 11178276 Free PMC article.

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References

1. Hartwell LH, Hopfield JJ, Leibler S, Murray AW. From molecular to modular cell biology. Nature. 1999;402:C47–52. doi: 10.1038/35011540. - DOI - PubMed
1. Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, Staudt LM, Hudson J Jr, Boguski MS, et al. The transcriptional program in the response of human fibroblasts to serum. Science. 1999;283:83–87. doi: 10.1006/abio.2000.4611. - DOI - PubMed
1. Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. . Science. 1995;270:467–470. - PubMed
1. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999;285:901–906. doi: 10.1126/science.285.5429.901. - DOI - PubMed
1. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA . 1998;95:14863–14868. - PMC - PubMed

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[1] Hartwell LH, Hopfield JJ, Leibler S, Murray AW. From molecular to modular cell biology. Nature. 1999;402:C47–52. doi: 10.1038/35011540. - DOI - PubMed

[2] Hartwell LH, Hopfield JJ, Leibler S, Murray AW. From molecular to modular cell biology. Nature. 1999;402:C47–52. doi: 10.1038/35011540. - DOI - PubMed

[3] Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, Staudt LM, Hudson J Jr, Boguski MS, et al. The transcriptional program in the response of human fibroblasts to serum. Science. 1999;283:83–87. doi: 10.1006/abio.2000.4611. - DOI - PubMed

[4] Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, Staudt LM, Hudson J Jr, Boguski MS, et al. The transcriptional program in the response of human fibroblasts to serum. Science. 1999;283:83–87. doi: 10.1006/abio.2000.4611. - DOI - PubMed

[5] Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. . Science. 1995;270:467–470. - PubMed

[6] Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. . Science. 1995;270:467–470. - PubMed

[7] Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999;285:901–906. doi: 10.1126/science.285.5429.901. - DOI - PubMed

[8] Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999;285:901–906. doi: 10.1126/science.285.5429.901. - DOI - PubMed

[9] Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA . 1998;95:14863–14868. - PMC - PubMed

[10] Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA . 1998;95:14863–14868. - PMC - PubMed

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