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Comment
. 2000 Dec;106(11):1309-10.
doi: 10.1172/JCI11344.

Vascular atrophy and VEGFR-2 signaling: old theories of pulmonary emphysema meet new data

S D Shapiro  1
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Comment

Vascular atrophy and VEGFR-2 signaling: old theories of pulmonary emphysema meet new data

S D Shapiro. J Clin Invest. 2000 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Mechanisms of airspace enlargement in pulmonary emphysema. The traditional inflammatory cell hypothesis stipulates that cigarette smoke results in accumulation of inflammatory cells that release proteinases (neutrophil elastase [NE], macrophage elastase [MMP-12], and cysteine proteinases) disrupting extracellular matrix and basement membrane. Loss of cell-matrix attachment leads to apoptosis with loss of the entire alveolar unit. Proposed here is an alternative hypothesis whereby cell death is the primary stimulus with subsequent loss of matrix components resulting in loss of the alveolar unit.
See this image and copyright information in PMC

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