[Cardioprotective effect of glycyram in myocardial damage induced by isadrine]

Abstract

Experiments on rats with isadrine induced myocardial disorder showed that glycyrram reduces the extent of myocardial inflammatory edema, inhibits an increase in the level of marker enzymes (creatine kinase, lactate dehydrogenade, asparatate aminotransferase) in the blood serum, prevents a decrease in the myocardial glycogen and an increase in the total lipids, inhibits increase in the lipid peroxidation and decrease in the antioxidant activity in the blood, and improves the ECG characteristics. These data suggest that glycyrram is a promising agent for the treatment of cardiac disorders accompanied by inflammatory and necrotic changes in myocardium, including myocarditis and myocardial infarction.