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. 2000 Dec 15;65(25):8763-6.
doi: 10.1021/jo001318c.

A facile synthesis of perfluoroalkyl vinyl iodides and their palladium-mediated cross-coupling reactions

M P Jennings  1 , E A Cork, P V Ramachandran
Affiliations

A facile synthesis of perfluoroalkyl vinyl iodides and their palladium-mediated cross-coupling reactions

M P Jennings et al. J Org Chem. .

Abstract

Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a facile synthesis of potentially useful fluoroorganic intermediates.

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