Review
doi: 10.1016/s0167-5699(00)01745-x.
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
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- PMID: 11114420
- DOI: 10.1016/s0167-5699(00)01745-x
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Review
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
Immunol Today.
2000 Dec.
Abstract
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
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