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Review
. 2000 Dec;21(12):611-4.
doi: 10.1016/s0167-5699(00)01745-x.

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

L L Lanier  1 , A B Bakker
Affiliations
Review

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

L L Lanier et al. Immunol Today. 2000 Dec.

Abstract

DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.

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