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Multicenter Study
. 2000 Dec;128(6):1043-50;discussion 1050-1.
doi: 10.1067/msy.2000.110848.

Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series

O Alsanea  1 , N Wada, K Ain, M Wong, K Taylor, P H Ituarte, P A Treseler, H U Weier, N Freimer, A E Siperstein, Q Y Duh, H Takami, O H Clark
Affiliations
Multicenter Study

Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series

O Alsanea et al. Surgery. 2000 Dec.

Abstract

Background: The aggressiveness of familial non-medullary thyroid cancer (FNMTC) has been a subject of debate. The purpose of the study was to determine whether FNMTC is more aggressive than sporadic thyroid cancer.

Methods: A multicenter retrospective matched-case control study of FNMTC versus sporadic non-medullary thyroid cancer was conducted. Disease-free survival (time to recurrence) for both groups was compared.

Results: Forty-eight familial cases were compared with 144 age-, gender-, and stage-matched controls. Patients with FNMTC had a significantly shorter disease-free survival compared with sporadic non medullary thyroid cancer. Patients with FNMTC who presented with evidence of distant metastasis, or who were from families with more than 2 thyroid cancer-affected members, had the worst prognosis. The available staging systems were less likely to predict the outcome in patients with FNMTC than in patients with sporadic non-medullary thyroid cancer unless one accounted for the strength of family history in the staging system.

Conclusions: FNMTC is more aggressive than sporadic non-medullary thyroid cancer. The best predictors of a poor outcome in patients with FNMTC are the number of family members affected by thyroid cancer and evidence of distant metastasis.

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