Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2000 Nov;17(4):337-9.
doi: 10.1007/BF02782201.

Pathologic rupture of the spleen during induction with ATRA in a patient with acute promyelocytic leukemia

R Hernández  1 , M C del Cañizo, C López, M I González, M L Vázquez, M D Caballero, J F San Miguel
Affiliations
Case Reports

Pathologic rupture of the spleen during induction with ATRA in a patient with acute promyelocytic leukemia

R Hernández et al. Med Oncol. 2000 Nov.

Abstract

Pathological rupture of the spleen is a rare but well recognized complication in hematological malignancies. Early clinical recognition of this life-threatening complication is necessary for rapid intervention. Here, we report on the case of a 26-year-old woman with acute promyelocytic leukemia who presented rupture of the spleen on day +2 of treatment with ATRA plus idarrubicin. In patients with acute leukemia, the presence of a painful abdomen and a sudden drop in hemoglobin levels, should alert of a possible splenic rupture, even without additional symptoms. This would facilitate an early treatment intervention with no modification to the chemotherapy schedule.

PubMed Disclaimer

References

    1. Leuk Lymphoma. 1998 May;29(5-6):613-6 - PubMed
    1. Ann Hematol. 1994 Mar;68(3):143-4 - PubMed
    1. J Trauma. 1996 Aug;41(2):214-8 - PubMed
    1. Ann Hematol. 1996 Dec;73(6):297-302 - PubMed
    1. Ann Hematol. 1999 Feb;78(2):91-2 - PubMed

Publication types

MeSH terms