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Review
. 2000 Dec;8(12):565-70.
doi: 10.1016/s0966-842x(00)01875-8.

Why Helicobacter pylori has Lewis antigens

B J Appelmelk  1 , M A Monteiro, S L Martin, A P Moran, C M Vandenbroucke-Grauls
Affiliations
Review

Why Helicobacter pylori has Lewis antigens

B J Appelmelk et al. Trends Microbiol. 2000 Dec.

Abstract

In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

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