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. 1976 Nov 15;32(11):1387-9.
doi: 10.1007/BF01937390.

Beta-adrenergic receptors in rat myocardium: direct detection by a new fluorescent beta-blocker

E Melamed, M Lahav, D Atlas

Beta-adrenergic receptors in rat myocardium: direct detection by a new fluorescent beta-blocker

E Melamed et al. Experientia. .

Abstract

A new fluorescent beta-blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to rats. Multiple fluorescent 9-AAP binding sites were observed on cardiac muscle cells in frozen sections. Intensity and density of cardiac 9-AAP fluorescence were markedly reduced following pretreatment with (+/-)- and (-)-propranolol but not with (+)-propranolol. Our findings suggest that 9-AAP may label beta-adrenergic receptor sites in rat myocardium.

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