Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Nov 27;11(17):3737-41.
doi: 10.1097/00001756-200011270-00029.

Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques

O Wirths  1 , S Weickert, K Majtenyi, L Havas, P J Kahle, M Okochi, C Haass, G Multhaup, K Beyreuther, T A Bayer
Affiliations

Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques

O Wirths et al. Neuroreport. .

Abstract

The contribution of alpha-synuclein accumulation in Alzheimer's disease (AD) plaques is currently a matter of scientific debate. In the present study antisera against the N- and C-terminus, the full-length protein and the central so-called non-amyloid component (NAC) domain of the alpha-synuclein protein were used to address this question in brains of cases with typical AD and of cases with the Lewy body (LB) variant of AD. In typical AD cases, none of the antisera revealed evidence for co-accumulation of alpha-synuclein with extracellular A beta peptides in plaques or in dystrophic neurites decorating the plaque core. Interestingly, cases with mixed pathology of the LB variant of AD revealed accumulation of alpha-synuclein in LBs and in dystrophic neurites of A beta plaques.

PubMed Disclaimer

Publication types