Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jan;45(1):319-23.
doi: 10.1128/AAC.45.1.319-323.2001.

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

F Depardieu  1 , P Courvalin
Affiliations

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

F Depardieu et al. Antimicrob Agents Chemother. 2001 Jan.

Abstract

Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Secondary structure of the peptidyl transferase loop in domain V of 23S rRNA. The mutated position in S. pneumoniae BM4455 is indicated by a square. The positions of the other binding sites of streptogramins (m2A2503-U2504) are indicated by a circle. Nucleotide sequence and numbering are those of E. coli 23S rRNA, and the corresponding S. pneumoniae numbering is given in parentheses.
See this image and copyright information in PMC

References

    1. Arevalo M A, Tejedor F, Polo F, Ballesta J P. Protein components of the erythromycin binding site in bacterial ribosomes. J Biol Chem. 1988;263:58–63. - PubMed
    1. Brisson-Noel A, Trieu-Cuot P, Courvalin P. Mechanism of action of spiramycin and other macrolides. J Antimicrob Chemother. 1988;22(Suppl. B):13–23. - PubMed
    1. Comité de l'Antibiogramme de la Société Française de Microbiologie. Zone sizes and breakpoints for non-fastidious organisms. Clin Microbiol Infect. 1996;2(Suppl.):1–49. - PubMed
    1. de Bethune M P, Nierhaus K H. Characterisation of the binding of virginiamycin S to Escherichia coli ribosomes. Eur J Biochem. 1978;86:187–191. - PubMed
    1. Di Giambattista M, Chinali G, Cocito C. The molecular basis of the inhibitory activities of type A and type B synergimycins and related antibiotics on ribosomes. J Antimicrob Chemother. 1989;24:485–507. - PubMed

Publication types

MeSH terms