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Review
. 2000 Dec 19;97(26):14022-4.
doi: 10.1073/pnas.97.26.14022.

c-Jun N-terminal kinase (JNK) repression during the inflammatory response? Just say NO

J P Hall  1 , E Merithew, R J Davis
Affiliations
Review

c-Jun N-terminal kinase (JNK) repression during the inflammatory response? Just say NO

J P Hall et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Alignment of amino acid sequences of human MAP kinases that correspond to the region surrounding cysteine-116 in JNK1. Secondary structure was taken from ref. . Numbers indicate residue positions in JNK1.
Figure 2
Figure 2
The atomic structure of JNK3 (24) is illustrated. (A) Ribbon representation of the inactive JNK3 structure (cyan) in complex with AMP-PNP (magenta). Specific residues involved in nucleotide binding and Cys-154 are shown in orange. Oxygens are shown in red, nitrogens in blue, sulfurs in yellow, and magnesium in off-white. (B) Close-up view of the active site of JNK3. Colors and orientation are the same as in A. Specific nucleotide contacts and Cys-154 are labeled, and the hydrogen bonds to the nucleotide are shown. The Protein Data Bank entry (1JNK) indicates that the hydrogen bonding contacts of N152 are with the O3′ hydroxyl of the ribose (compare with ref. 24). The images were generated with molscript (31) and rendered with Raster3D (32).
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Comment on

References

    1. Park H-S, Huh S-H, Kim M-S, Lee S H, Choi E-J. Proc Natl Acad Sci USA. 2000;97:14382–14387. - PMC - PubMed
    1. Nathan C. FASEB J. 1992;6:3051–3064. - PubMed
    1. Nathan C, Xie Q W. J Biol Chem. 1994;269:13725–13728. - PubMed
    1. Grisham M B, Jourd'Heuil D, Wink D A. Am J Physiol. 1999;276:G315–G321. - PubMed
    1. Nathan C. J Clin Invest. 1997;100:2417–2423. - PMC - PubMed

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