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Review
. 2000 Dec 19;97(26):14035-7.
doi: 10.1073/pnas.97.26.14035.

Imprinted expression of small nucleolar RNAs in brain: time for RNomics

W Filipowicz  1
Affiliations
Review

Imprinted expression of small nucleolar RNAs in brain: time for RNomics

W Filipowicz. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Short guide to the structure (A) and biogenesis (B) of guide snoRNAs. (A) Schematic structure of the C/D-box and H/ACA-box snoRNAs, with conserved sequence elements and base-paired target RNAs indicated. Most snoRNAs contain one rather than two functional modification domains, although H/ACA-box snoRNAs always have a conserved hairpin-hinge-hairpin-tail secondary structure. The pseudouridylation pocket forms two short duplexes (3–10 bp) with the target RNA, leaving the uridine residue to be isomerized unpaired. snoRNAs of each class are associated with a set of specific proteins which are not shown. (B) Different strategies of snoRNA expression. In the yeast Saccharomyces cerevisiae, most of the snoRNA genes are transcribed as either mono- or polycistronic units, and only a few are encoded in introns. In all established cases, vertebrate guide snoRNAs originate from introns of either protein-coding or noncoding RNA polymerase II-transcribed genes. Sequences corresponding to mature snoRNAs are shown as filled-in boxes, and exons, as open boxes. Arrows indicate transcription initiation sites. Transcription start sites for the tandemly repeated brain-expressed snoRNA genes are not known.
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