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Review
. 2000 Dec;122(3):291-5.
doi: 10.1046/j.1365-2249.2000.01400.x.

X-linked lymphoproliferative syndrome

D L Nelson  1 , C Terhorst
Affiliations
Review

X-linked lymphoproliferative syndrome

D L Nelson et al. Clin Exp Immunol. 2000 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Interactions between cell surface molecules take place at the interface between an antigen-presenting cell (e.g. Epstein–Barr virus (EBV)-infected B cell) and an activated T cell.
Fig. 2
Fig. 2
SLAM-associated protein (SAP) is a small cytoplasmic protein that binds to SLAM in a resting T cell and to phosphorylated SLAM in an activated T cell.
Fig. 3
Fig. 3
SLAM-associated protein (SAP) can block recruitment of the tyrosine phosphatase SHP-2.
Fig. 4
Fig. 4
The tyrosine phosphatase SHP-2 is activated upon binding to Phospho-SLAM via its SH2 domains.
Fig. 5
Fig. 5
Expression of the SLAM-associated protein (SAP) and SLAM genes during in vitro T cell activation.
See this image and copyright information in PMC

References

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    1. Purtilo DT, Cassel C, Yang JP. Letter: Fatal infectious mononucleosis in familial lymphohistiocytosis. N Engl J Med. 1974;291:736. - PubMed
    1. Provisor AJ, Lacuone JJ, Chilcote RR, Neiburger RG, Crussi FG. Acquired agammaglobulinemia after a life-threatening illness with clinical and laboratory features of infectious mononucleosis in three related male children. N Engl J Med. 1975;293:62–65. - PubMed
    1. Purtilo DT, Grierson HL, Davis JR, Okano M. The X-linked lymphoproliferative disease: from autopsy toward cloning the gene 1975–1990. Pediatr Pathol. 1991;11:685–710. - PubMed
    1. Seemayer TA, Gross TG, Egeler M, et al. X-linked lymphoproliferative disease: twenty-five years after the discovery. Pediatr Res. 1995;38:471–8. - PubMed

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