Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Sep;1(1):77-84.
doi: 10.1007/s11912-999-0014-6.

In vitro chemosensitivity testing and mechanisms of drug resistance

K Tewari  1 , A Manetta
Affiliations
Review

In vitro chemosensitivity testing and mechanisms of drug resistance

K Tewari et al. Curr Oncol Rep. 1999 Sep.

Abstract

This article reviews the cellular mechanisms that confer biochemical and clinical resistance to antineoplastic agents used in the adjunctive treatment and palliation of metastatic ovarian cancer. The historical development of in vitro chemosensitivity testing is also reviewed, along with published experiences of various investigators with assays used in clinical ovarian cancer treatment programs. Finally, an investigational protocol for chemosensitivity testing is proposed.

PubMed Disclaimer

References

    1. J Natl Cancer Inst. 1993 Nov 3;85(21):1732-42 - PubMed
    1. Cancer Res. 1991 Nov 15;51(22):6059-65 - PubMed
    1. Cancer. 1997 Apr 1;79(7):1447-50 - PubMed
    1. Med Biol. 1984;62(6):338-43 - PubMed
    1. Cancer. 1996 Mar 15;77(6):1020-5 - PubMed

LinkOut - more resources