Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Mar;2(2):199-204.
doi: 10.1007/s11912-000-0094-9.

Epstein-Barr virus and Hodgkin's disease

L M Weiss  1
Affiliations
Review

Epstein-Barr virus and Hodgkin's disease

L M Weiss. Curr Oncol Rep. 2000 Mar.

Abstract

Approximately 40% to 50% of cases of Hodgkin's disease occurring in Western populations are associated with the Epstein-Barr virus (EBV). In these cases, EBV is found in the neoplastic elements, the Reed-Sternberg and Hodgkin's cells. EBV is probably not present in all cases, but neither have any other viruses been found in the cases that are EBV-negative. EBV may play a role in the pathogenesis of Hodgkin's disease by the activation of anti-apoptotic factors in a premalignant germinal center B-lymphocyte. Regardless of their role in etiology or pathogenesis, EBV-latent antigens may represent a target for possible immune therapy.

PubMed Disclaimer

References

    1. Am J Pathol. 1987 Oct;129(1):86-91 - PubMed
    1. Annu Rev Immunol. 1998;16:471-93 - PubMed
    1. Am J Pathol. 1999 Sep;155(3):941-7 - PubMed
    1. Br J Haematol. 1992 Dec;82(4):689-94 - PubMed
    1. Lancet. 1964 Mar 28;1(7335):702-3 - PubMed

LinkOut - more resources