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. 2001 Jan 1;29(1):33-6.
doi: 10.1093/nar/29.1.33.

CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins

E V Kriventseva  1 , W Fleischmann, E M Zdobnov, R Apweiler
Affiliations

CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins

E V Kriventseva et al. Nucleic Acids Res. .

Abstract

The CluSTr (Clusters of SWISS-PROT and TrEMBL proteins) database offers an automatic classification of SWISS-PROT and TrEMBL proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences. Analysis has been carried out for different levels of protein similarity, yielding a hierarchical organisation of clusters. The database provides links to InterPro, which integrates information on protein families, domains and functional sites from PROSITE, PRINTS, Pfam and ProDom. Links to the InterPro graphical interface allow users to see at a glance whether proteins from the cluster share particular functional sites. CluSTr also provides cross-references to HSSP and PDB. The database is available for querying and browsing at http://www.ebi.ac.uk/clustr.

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Figures

Figure 1
Figure 1
Entity-Relationship diagram for the CluSTr database.
Figure 2
Figure 2
Searching the CluSTr database. Results for a query of ‘human sodium transport’ proteins. The table contains accesssion numbers of proteins with the words ‘human’ and ‘sodium transport’ in their annotation and the corresponding clusters at different Z-levels.
Figure 3
Figure 3
A cluster of the human sodium:neurotransmitter symporter proteins. The presentation contains general information, lists of proteins, their description and InterPro-based domain description of the cluster. At the bottom of the page are links to the InterPro graphical representation and the SRS-generated list of clustered proteins as well as links to the HSSP and PDB databases.
See this image and copyright information in PMC

References

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