Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;26(2):105-11.
doi: 10.1007/BF00278436.

Changes in the mitotic cycle induced by alpha-solanine

D Kirk, U Mittwoch

Changes in the mitotic cycle induced by alpha-solanine

D Kirk et al. Humangenetik. 1975.

Abstract

Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Invest Dermatol. 1972 Jul;59(1):114-20 - PubMed
    1. Toxicol Appl Pharmacol. 1971 May;19(1):81-92 - PubMed
    1. J Cell Physiol. 1969 Dec;74(3):235-44 - PubMed
    1. Teratology. 1973 Dec;8(3):349-57 - PubMed
    1. Br J Exp Pathol. 1971 Apr;52(2):186-91 - PubMed