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Clinical Trial
. 2000 Nov;50(11):386-8.

Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling postoperative nausea and vomiting

S R Muhammad  1 , S Z Abbas, S Q Abbas
Affiliations
  • PMID: 11126816
Clinical Trial

Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling postoperative nausea and vomiting

S R Muhammad et al. J Pak Med Assoc. 2000 Nov.

Abstract

Objective: To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy.

Setting: Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi.

Subjects: Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecystectomy by a single surgeon.

Main outcome measures: Postoperative nausea and vomiting (PONV) at 2 hours and within 24 hours and requirement of rescue antiemetic.

Results: Tropisetron was better than Metoclopramide and placebo in controlling postoperative nausea and vomiting.

Conclusion: Tropisetron when given at induction at a dose of 2 mg. intravenously prevents PONV better than Metoclopramide and placebo in 2 hours and 24 hours. It also reduces the need for rescue antiemetic significantly.

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