[Adverse effects of drug interactions of cyclosporin A and tacrolimus therapy]

Abstract

In recent years cyclosporin A and tacrolimus therapy have been more and more popular in immunosuppressive treatment and in management of various diseases. Most often both drugs are administered to patients on polytherapy. Despite the very strong activity of these medications and common adverse effects, the literature on the subject infrequently associates these phenomena with the possibility of interaction with other drugs or factors causing changes in cyclosporin A, tacrolimus or their metabolites levels in the blood, or else with changes in other pharmacokinetic parameters. It seems that drug monitored therapy will significantly decrease the occurrence of adverse effects, and in the future it may possibly explain whether such effects are the consequence of drug interaction. The paper presents the interactions between cyclosporin A and tacrolimus on the one hand, and other medications or factors which change the blood concentration values or other pharmacokinetic parameters of both drugs.